Figure 2.
(a) Pirh2 NTD. N lobe shows the interleaved Zn1 and Zn2 sites
and a four-cysteine-coordinated Zn3 site. C lobe shows
left-handed -spiral
structure with three CCHC motifs coordinating Zn4, Zn5 and Zn6.
(b) Pirh2 RING domain, showing the interleaved Zn7 and Zn8
sites. (c) Pirh2 CTD, showing Zn9 site coordinated by four
cysteines. The nine zinc atoms are shown as spheres.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nat Struct Biol
(2008,
15,
1334-1342)
copyright 2008.
-spiral
structure with three CCHC motifs coordinating Zn4, Zn5 and Zn6.
(b) Pirh2 RING domain, showing the interleaved Zn7 and Zn8
sites. (c) Pirh2 CTD, showing Zn9 site coordinated by four
cysteines. The nine zinc atoms are shown as spheres.