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Figure 2.
Figure 2: Details of SRA–DNA interactions. a, The 5mC  G
base pair is shown in the front, and the adjoining G C
base pair is in the back. b, Planar stacking contacts of the
extrahelical 5mC with Y471 and Y483 (left image). Omit electron
densities, contoured at 4  and
5 above
the mean, respectively, are shown for omitting 5mC (blue) or the
methyl group (red) (right image). c, The hydrogen bond
interactions with the polar atoms of 5mC. The double-dotted
lines indicate van der Waals contacts with the methyl group of
ring carbon C5. d, H450 forms a hydrogen bond from the minor
groove side with cytosine of G C
pair at position 5 (see Fig. 1a). e, Network of internal polar
interactions centred on residues H447 and S464. Gua, guanine. f,
Network of internal charged interactions centred on residues
R541 and D560. Distances are shown in angstroms.
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