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Figure 2.
Binding of VX-680 in the active site of AurA/TPX2. (A) The
electron density of VX-680 contoured at 1.5[sigma] from the
final 2fo-fc map. The AurA carbons are shown in green, inhibitor
carbons in yellow, oxygens in red, nitrogens in blue, sulfur in
orange, and water molecules in light blue. (B) Interactions of
VX-680 with the active site of AurA when TPX2 is bound. The
backbone tracing is in gray and hydrogen bonds are shown as
dotted black lines. (C) Interactions of VX-680 with the active
site of AurA without TPX2 bound (adapted from Cheetham et al.
2007 and reprinted with permission from Elsevier
[copyright]2007).
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