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Figure 2.
Figure 2. Crystal Structure of SapD
(A) Proposed SapD
dimer formation. SapD dimers are formed by contacts between
hairpin turns connecting α2″, α3′ and N-termini of helices
α3′ of molecules B and C, red ellipse indicates local C2
axis. In triclinic SapD, sulfate ions (marked SO4) are bound by
Lys10 and Arg17 of molecules A, B, and C but not D. Tyr54
(iodinated in SapD-iodoTyr54), Phe4, and Phe50 (magenta) shield
the hydrophobic inner cavity.
(B) Sulfate binding sites
formed inter- and intramolecularly by Lys10 and Arg17 of SapD
molecules A and B. Electron density is contoured at 1.3 σ
level. The distance between the two sulfate sulfur atoms is 8.3
Å.
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