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Figure 2.
FIGURE 2. P. abyssi exosome RNA recognition cleft. Rrp41
and Rrp42 subunits are colored in blue and light brown,
respectively. Heterodimers forming the hexameric ring are
assigned 1 to 3 and numbers in parentheses identify residues
from the same dimer. a, schematic representation of the N1 to N5
binding sites. Residues involved in RNA interaction are labeled
and shown in sticks. Residues mutated in this work are indicated
with a colored star. b, schematic representation showing the
RNA-exosome interactions in detail. c, stereo view of the N1
nucleotide binding site. The |F[o]| - |F[c]| electron density
map contoured at 4  is superposed on the
solvent atoms.
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