Figure 2.
(a) Shown is the structure of tamoxifen-bound ER (PDB
code 3ERT) as a ribbon diagram. Helices 3–5 are colored pink,
and helix 12 is colored red. (b) Molecular modeling suggests
that the mutation L536S of ER promotes
a stabilizing interaction between helix 12 and Glu380 in helix 3.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nat Chem Biol
(2008,
4,
241-247)
copyright 2008.
(PDB
code 3ERT) as a ribbon diagram. Helices 3–5 are colored pink,
and helix 12 is colored red. (b) Molecular modeling suggests
that the mutation L536S of ER