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Figure 2.
Figure 2. Structure of the E. coli Dihydroneopterin
Pyrophosphatase
(A) Ribbon diagram of the structure of
DHNTPase in complex with its product, pyrophosphate. Residues of
the Nudix signature sequence, Arg-29 and Glu-117, are shown as
green sticks. The secondary structural elements are labeled L
for loops, β for strands, and α for helices.
(B) Ribbon
diagram of the overlap of monomers A, B, and C (turquoise,
cornflower blue, and blue, respectively) with their
pyrophosphate and sulfate molecules.
(C) Molecular surface
of the complex structure (monomer A, closed).
(D) Ribbon
diagram of the overlap of monomer A (complex structure;
turquoise) and monomer D (ligand-free structure, open;
orange-red).
(E) Molecular surface of the ligand-free
structure (open).
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