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Figure 2.
Figure 2. HEF2/ERH interacts with transcription factors and
cell-cycle regulators. (A), recently identified interactions
between mammalian HEF2/ERH and transcription factors.[31-37]
Protein-protein interactions are shown by a connecting line with
an arrowhead on each end. Interactions between enzyme-substrate
pairs are indicated by an arrow pointing to the target. (B), an
interaction network of HEF2/ERH Drosophila ortholog, e(r),
compiled from interactions in the Drosophila Interactions
Database (http://proteome.wayne.edu/PIMdb.html) using the IM
Browser.[21] Node coloring was done manually using the IM
Browser to indicate functions of corresponding proteins: green,
transcription; red, cell cycle; yellow, other; and white,
unknown function. Line coloring was done automatically by the IM
Browser and indicate the source of the information on the
interaction: blue, yeast two hybrid[38]; green, yeast two
hybrid[39]; magenta, genetic interaction; cyan, supplemental
prediction from C. elegans protein interactions; yellow,
supplemental predictions from yeast protein interactions; and
red, interaction indicated by more than one of the above sources.
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