Figure 2.
Fig. 2. Key interactions of the TRAP-tail with P.
falciparum aldolase. (A) TRAP-tail residues D604, W605, and N606
(magenta) interacting with PfAldo residues (light blue). C[ ]positions are marked
as spheres. Selected hydrophobic contacts are shown with red
lines and distances in angstroms. The hydrogen bond between the
indole nitrogen of TRAP-W605 and the carboxylate of E40, and the
interactions between TRAP-N606 with R153 and K151, and of the
backbone oxygen of TRAP-D604 with R48, are depicted in black.
(B) Sequence alignment of the C-terminal TRAP-tail residues of
three plasmodial species. Identical residues are shaded in red.
All TRAP residues involved in contacts with aldolase are well
conserved in several Plasmodium species.
]positions are marked
as spheres. Selected hydrophobic contacts are shown with red
lines and distances in angstroms. The hydrogen bond between the
indole nitrogen of TRAP-W605 and the carboxylate of E40, and the
interactions between TRAP-N606 with R153 and K151, and of the
backbone oxygen of TRAP-D604 with R48, are depicted in black.
(B) Sequence alignment of the C-terminal TRAP-tail residues of
three plasmodial species. Identical residues are shaded in red.
All TRAP residues involved in contacts with aldolase are well
conserved in several Plasmodium species.