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Figure 2.
(a) Left, 2'OMT domain colored from blue (N terminus) to red
(C terminus). Poorly ordered loop is gray. AdoHcy (magenta) and
G5'ppp5'G (blue) substrates are shown. Right, 2'OMTase active
sites of VP4 (purple) and VP39 (cyan). Carbon atoms and bonds of
significant residues are colored gray. VP4 ligands colored as at
left; VP39 AdoHcy and m^7G5'ppp5'G are marine and orange,
respectively. Red and yellow spheres represent cap analog 2'-O
and AdoHcy sulfur, respectively. (b) N7MT domain and AdoHcy, as
in a. Right, stereo view of N7MTase active sites of VP4 and
Ecm1. Carbon atoms and bonds of VP4 are gray, with guanine bases
purple and AdoHcy pink. Ecm1 is in olive, with cap analog orange
(blue sphere, N7) and AdoHcy lime (yellow spheres, sulfurs).
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