|
Figure 2.
Figure 2. Model of Cdk7 (as enzyme) and Cdk2 (as substrate).
The model was generated by imposing constraints derived from
mutagenesis studies. Cdk7 is shown in green and Cdk2 in yellow.
(A) Cdk7 activation segment in the active conformation (blue)
was modelled on active Cdk2. Cdk2 activation segment is shown in
cyan. Residues 158-162 are missing. A red dotted curve indicates
the path that Cdk2 activation segment should follow to reach
Cdk7 active site (indicate by D137 and K139 colored in white).
(B) Cdk2  D
helix (in orange) inserts in between Cdk7 lobes close to its
hinge region (in blue).
|
