|
Figure 2.
Figure 2. Structure of Zyg9-TOG3
(A) Zyg9 TOG3 has seven
HEAT repeats. HR0 contains helices 0A and 0B (red) linked by a
14 residue loop (T0). The six HEAT repeats that follow (blue
helices, HR1–HR6) form the conserved TOG domain structure. In
this view, the A helices (1A–6A) are in the front, the B
helices (1B–6B), in the rear; turns between A and B helices of
each repeat (T1–T6) are at the bottom, and interrepeat turns
(T2-3 and T3-4) are at the top. The HR5 A helix is broken by a
nonhelical linker into helices 5A1 and 5A2. HR6 packs onto HR5
with a right-handed 45° twist. There is a short β-ribbon
(yellow strands, S0 and S1) at the N terminus.
(B) As in
(A), but viewed from the bottom (structure rotated by 90°).
(C) As in (A), but structure rotated by 180°.
|
