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Figure 2.
FIGURE 2. Electrostatic interactions of the HY5 LZ
homodimer. A, helical wheel diagrams of the HY5 LZ homodimer.
The view is from the N terminus. Heptad positions are labeled
a-g. Solid and dashed gray lines indicate electrostatic
attractions between oppositely charged residues and hydrogen
bonds, respectively. Boxed amino acid residues are within the
putative trigger sites. The intrahelical hydrogen bond between
Leu^8 and Glu^9 in strand B was omitted for simplicity. B, front
(upper) and back (lower) views of electrostatic surface
potential representations of the HY5 LZ dimer. All positively
charged residues and some negatively charged residues that
interact with positive charges are labeled. Surface potentials
were calculated using GRASP (59).
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