Figure 2.
Figure 2. Structure-based sequence alignment of RAD against
close structural homologues identified by DALI.[38] Only the
sequences of the polypeptides present in the PDB entries are
displayed. The positions of -helices
are indicated by red shading and the locations of the W,W,W
motifs are boxed. EH has a Phe in the third position according
to the structural alignment, although the adjacent residue is a
Trp (also boxed). Residues showing large chemical shifts in
ARR10-B upon binding DNA are indicated with blue bars. Residues
that contact DNA in the crystal structure of EH are also shown
as bars: blue bars representing interactions with the phosphate
backbone and green bars indicating interactions with the DNA
bases.
The above figure is reprinted
by permission from John Wiley & Sons, Inc.:
Proteins
(2006,
65,
1041-1045)
copyright 2006.
-helices
are indicated by red shading and the locations of the W,W,W
motifs are boxed. EH has a Phe in the third position according
to the structural alignment, although the adjacent residue is a
Trp (also boxed). Residues showing large chemical shifts in
ARR10-B upon binding DNA are indicated with blue bars. Residues
that contact DNA in the crystal structure of EH are also shown
as bars: blue bars representing interactions with the phosphate
backbone and green bars indicating interactions with the DNA
bases.