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Figure 2.
Figure 2. Comparison of NAD^+ and NAD^+-Analog Bound
Sirtuin Structures
Structural alignment of
Sir2Tm-acetylated p53 peptide-NAD^+ (blue), Hst2Sc-acetylated
histone H4 peptide-carba-NAD^+ (green), and Sir2Af2-NAD^+ (pink)
based on atoms in the adenine ring, adenine ribose,
nicotinamide, and the catalytic histidine. Acetyl lysine and
active site residues for the corresponding structures are
indicated.
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