|
Figure 2.
Illustration of some possible folds of the [beta]-sheet
domain as a result of the insertion L30c. The inserted sequence
(red) contains Strand II and Turn T-2. (A) In the simplest
scenario, the inserted structure loops out at the insertion
site, i.e., at Turn T-1. The neighboring structure retains the
native conformation, leaving the identical parent sequence
(yellow) unchanged. (B) In a second scenario, the insert
sequence displaces the identical parent sequence, forcing it to
loop out at Turn T-2. (C) In yet another scenario (the one that
is observed), the sequence that is displaced in B continues so
as to displace the sequence in Strand III. The structure will
then be forced to loop out at T-3. In going from scenario B to
C, the wild-type turn structure T-2 (Gly-Ile-Gly) is restored.
In contrast, however, Strand II now replaces Strand III, causing
substitutions in this region.
|
