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Figure 2.
Figure 2. Domain arrangement and structural alignment of smPurL
and lgPurL. A: Domain arrangement of PurM, ThiL, smPurL, and
lgPurL proteins. PurM and ThiL are homodimers. smPurL (gray) and
the central domain of lgPurL (blue) have the same domain
arrangement as a PurM dimer. lgPurL has two additional domains
as compared with smPurL. The N-terminal domain homologous to the
PurS protein is colored green and the C-terminal glutaminase
domain is colored red. B: Stereo ribbon diagram of a
superposition of smPurL (gray) and residues 183-960 of lgPurL
from S. typhimurium (blue). The lgPurL N-terminal domain of
unknown function and the C-terminal glutaminase domain are
colored green and red, respectively. These extra domains of
lgPurL correspond to the PurS (TM1244) and PurQ (TM1245)
proteins in T. maritima. The structures were aligned using the
DALI server.
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