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Figure 2.
Figure 2. Critical Interactions of Bortezomib with Active
Site Residues Responsible for Chymotryptic and Caspase-like
Activities
Schematic overview of bortezomib bound to (A)
the chymotryptic-like active site and (B) the caspase-like
active site. Hydrogen bonds with correlated distances in Å are
shown as brown dashed lines, whereas characteristic oxygen and
nitrogen atoms are presented in red and blue capitals. The amino
acid, which is responsible for the character and binding mode to
the P3-pyrazine-2-carboxyl side chain of the inhibitor is
located at the adjacent b-type subunit and shown in gray. The
defined water molecule forming tight hydrogen bonds to the
protein is depicted in magenta, and the inhibitor is shown in
green.
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