Figure 2. Figure 2. Crystal structure of USP7 NTD bound to p53 site 364-AHSS-367. (a) Transparent surface diagram of USP7 NTD bound by p53 mutant peptide 358-EAGGARAHSS-367 (blue). (b) Detailed interactions between USP7 (light gray) and p53 (dark gray). (c) Overlay of p53 peptides 359-PGGS-362 (red) and 364-AHSS-367 (turquoise) from USP7 complex structures.
The above figure is reprinted by permission from Macmillan Publishers Ltd: Nat Struct Mol Biol (2006, 13, 285-291) copyright 2006.