|
Figure 2.
Figure 2. The inhibitor-binding site in subunit A of mouse
AMF. The carbon and phosphorus atoms of the bound inhibitor
molecule are shown in cyan and green, respectively. The bound
inhibitor molecule is superimposed on the F[o] -F[c] omit
electron density map (contoured at 15.0s (red) and 3.0s (violet)
for (a), (b), (g), and (h), and at 15.0s (red) and 4.0s (violet)
for (c), (d), (e), and (f)). Possible hydrogen bonds are
indicated by broken lines (green). The bound water molecules are
shown as ball models (pink). (a) Acetate (in inhibitor-free
mAMF); (b) phosphate; (c) E4P; (d) A5P; (e) S6P; (f) 6PGA; (g)
F6P; (h) G6P (the bound ligand is modeled as the reaction
product F6P).
|
