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Figure 2.
Fig. 2. AvrPtoB mimics host RING-finger and U-box proteins. (A)
Structural alignment of the AvrPtoB CTD (the core fold) with the
RING-finger and U-box structures of Rbx1 [Protein Data Bank
(PDB) ID 1LDJ [PDB]
, Rag1 (PDB ID 1RMD [PDB]
), PrP19 (PDB ID 1N87 [PDB]
), and AtPUB14 (PDB ID 1T1H [PDB]
). (B) Visualization of the E2-binding site residues of Rbx1
with homologous regions in AvrPtoB and AtPUB14 [the polypeptide
backbone from the alignment in panel (A)]. The corresponding
residue numbers are indicated next to the amino acid. (C)
Structure-based sequence alignment of AvrPtoB, Rbx1, and AtPUB14
focusing on the conserved, core fold. Secondary structure of
AvrPtoB is indicated in blue above the sequence. Black
highlights the three putative E2-binding residues shown in panel
(B). The location of the AvrPtoB disordered insertion is
indicated.
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