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Figure 2.
Figure 2. HEAT Repeats in CRM1(A) Sequence alignment
between the middle regions of CRM1 and Trn1. Identically and
highly conserved residues are in inverse font and highlighted in
gray, respectively. The chymotrypsin cleavage site marks the
beginning of the C-terminal 70 kDa fragment. Colored bars
indicate helices observed from crystal structures; predicted
helices are in gray. The LMB site and residues implicated in
RanBP3 binding are indicated. Sequence numbering is that of
human Trn1 (top) and human CRM1 (bottom).(B) HEAT-repeat maps.
CRM1 is predicted to contain the same number of repeats as Trn1
and Impβ. The difference in sequence length is due to CRM1
having larger individual repeats (primarily repeats 1, 3, 7, 13,
15, and 19) and a long tail region. The C-terminal region of
Trn1 sometimes designated repeat 20 is labeled “C.” The
hashed bar shows where the mapping is uncertain.
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