Figure 2 - full size

 

Figure 2.
FIG. 2. Overlap of the unliganded O2 enzyme showing Arg-268 and adjacent residues with the observed position of acceptor (green) and UDP (magenta) of wild-type GTA. The position of the GalNAc residue (magenta) has been modeled after Patenaude et al. (6) and shows severe conflicts with the Arg-268 side chain that completely blocks the sugar residue from the active site.

The above figure is reprinted by permission from the ASBMB: J Biol Chem (2005, 280, 525-529) copyright 2005.