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Figure 2.
ig. 2. Stereoview of the environ-
ment of His87. The small lobe is
indicated in red and the large
lobe in blue. The inhibitor is
indicated in black. (a) In the
recombinant mouse C subunit,
His87 of the small lobe interacts
with the stble phosphoryation
site of Thr197 of the large lobe
and the carbonyl group of the
main chain of Glu86 interacts
with the side chain of Asng0. (b)
In the pocine heart C subunit,
His87 moves away from the
phosphate of Thr197 and the
side chain of Asng0 of the small
lobe interacts with the carbonyl
of Ala188 of the large lobe.
istances are given in A.
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