Figure 2.
Figure 2: Conformational changes in the active site accompany
HDV ribozyme cleavage. a, 3.4 Å experimental electron-density
map of the wild-type precursor HDV ribozyme (1 )
superimposed on the refined wild-type structure model (magenta)
and that of the C75U mutant (grey). b, Backbone alignment of the
precursor (magenta) and product (grey) ribozyme structures. c,
Stereo view of the aligned active sites of the precursor
(coloured) and product (grey) ribozyme structures.
Conformational changes were modelled using the C75U mutant
ribozyme structure, shown by arrows.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nature
(2004,
429,
201-205)
copyright 2004.
)
superimposed on the refined wild-type structure model (magenta)
and that of the C75U mutant (grey). b, Backbone alignment of the
precursor (magenta) and product (grey) ribozyme structures. c,
Stereo view of the aligned active sites of the precursor
(coloured) and product (grey) ribozyme structures.
Conformational changes were modelled using the C75U mutant
ribozyme structure, shown by arrows.