Figure 2.
Figure 2 Orientation of the pteridine ring for folates (cyan)
and antifolates (red). The Connolly surface for hDHFR is shown
in green and the contact distances of the nicotinamide ring of
NADPH are shown to the folate-reduction site.
The above figure is reprinted
by permission from the IUCr:
Acta Crystallogr D Biol Crystallogr
(2004,
60,
646-655)
copyright 2004.
