Figure 2.
Figure 2: MutY -DNA complex. a, Ribbon trace of the complex.
DNA is shown in gold, oxoG in magenta, the substrate adenine in
purple, the [4Fe -4S] domain in green, and the six-helix barrel
domain in cyan. The C-terminal domain is coloured by secondary
structure ( -strands,
blue; helices, red). The sulphur and iron atoms of the [4Fe -4S]
cluster are yellow and orange, respectively. See Supplementary
Fig. S4 for a topology diagram. b, Same structure as in a, but
rotated 90° towards the reader. The purple sphere indicates a
Ca^2+ ion that is occluded in a. c, Structures of MutT13 and the
EndoIII -DNA complex9. N and C termini are indicated.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nature
(2004,
427,
652-656)
copyright 2004.
-strands,
blue; helices, red). The sulphur and iron atoms of the [4Fe -4S]
cluster are yellow and orange, respectively. See Supplementary
Fig. S4 for a topology diagram. b, Same structure as in a, but
rotated 90° towards the reader. The purple sphere indicates a
Ca^2+ ion that is occluded in a. c, Structures of MutT13 and the
EndoIII -DNA complex9. N and C termini are indicated.