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Figure 2.
Figure 2. Stereo view showing the alternative binding modes
adopted by inhibitor (4) in the two structures (a) X(SSYI)bT.A4
and (b) X(SSYI)bT.B4. In a, the glycine spacer hydrogen bonds to
Gly216; the tosyl group of the inhibitor occupies the S3/S4
site. In b, the glycine spacer hydrogen bonds to Gly219; the
tosyl group points away from the enzyme, making contacts with a
symmetry-related molecule in the crystal (not shown).
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