Figure 2 - full size

 

Figure 2.
FIG. 2. Pyridoxal binding site. The molecule in the center is the pyridoxamine bound in the PLK·AMP-PCP-pyridoxamine complex. The surrounding residues are shown in green, and the hydrogen bonds between the pyridoxamine and the residues are shown as purple dashes. The corresponding residues in the PLK·ATP complex are in blue. A comparison of these structures reveals local conformational adjustments of the pyridoxal binding site when the substrates binds.

The above figure is reprinted by permission from the ASBMB: J Biol Chem (2004, 279, 17459-17465) copyright 2004.