Figure 2.
Fig. 2. Delineation and fitting of cadherin molecules to the
desmosome. With the C-cadherin x-ray structure as a template,
136 cadherin molecules were delineated in the region of
desmosome "P" (see Table 1). (A) Densities from the map, with
individual cadherin molecules in various colors and the membrane
in cyan. (B) A representative group of cadherin molecules
clustering at the midline and interacting predominantly at their
tips. (C to E) Three recurrent molecular interactions within the
molecular groups, referred to as W, S, and , respectively.
The x-ray structure for C-cadherin was fitted as a rigid body
with no changes within the structure itself. (G to I) The
resulting juxtaposition of EC1 domains, where each molecule has
a distinct ribbon color, calcium ions are brown, the
space-filling representation of the Trp2 side chain is dark
orange, and the HAV sequence has a light orange ribbon with
stick-like side chains.
The above figure is reprinted
by permission from the AAAs:
Science
(2003,
302,
109-113)
copyright 2003.
, respectively.
The x-ray structure for C-cadherin was fitted as a rigid body
with no changes within the structure itself. (G to I) The
resulting juxtaposition of EC1 domains, where each molecule has
a distinct ribbon color, calcium ions are brown, the
space-filling representation of the Trp2 side chain is dark
orange, and the HAV sequence has a light orange ribbon with
stick-like side chains.