Figure 2.
Fig. 2. (a) Stereo diagram of the ScT2-ATPase dimer. The
GHKL and transducer domains are colored gold and orange,
respectively. A 22-aa -hairpin unique to
eukaryotic topo II is colored light blue. ICRF-187 is shown as
blue spheres. All residues within 5 Å of the drug are
colored green. ADPNP is shown as spheres and colored by atom.
(b) Buried dimer surface area. This is a surface representation
of a single protomer seen from the dimer interface, showing
surfaces involved in dimer interactions. Distances between the
surfaces of each protomer were calculated with GRASP (29) and
range from 0 Å (white) to >7 Å (red). The
ICRF-187-binding pocket sits in the middle of the primary dimer
interface.
-hairpin unique to
eukaryotic topo II is colored light blue. ICRF-187 is shown as
blue spheres. All residues within 5 Å of the drug are
colored green. ADPNP is shown as spheres and colored by atom.
(b) Buried dimer surface area. This is a surface representation
of a single protomer seen from the dimer interface, showing
surfaces involved in dimer interactions. Distances between the
surfaces of each protomer were calculated with GRASP (29) and
range from 0 Å (white) to >7 Å (red). The
ICRF-187-binding pocket sits in the middle of the primary dimer
interface.