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Figure 2.
Fig. 2. Crystal structures of the ATP-binding site of the
WT LN40, BCK and LN40(A100P). a: The active site configuration
of the LN40–ADPnP complex in the presence of Mg^2+ and K^+.
Peaks above 3σ in an anomalous difference Fourier map are
contoured in light blue. b: The ATPγS bound BCK. c: The active
site configuration of the LN40(A100P)–ADPnP complex. The ATP
analogs (ADPnP and ATPγS) are shown in yellow bonds, the
protein carbonyl groups in gray bonds, the Mg^2+ ion is shown in
dark green, Na^+ ion in light blue, and K^+ ion dark purple.
Coordination of the monovalent cation is highlighted in dark
pink.
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