Figure 2 - full size

 

Figure 2.
Figure 2. Space-Filling Representation of sEGFR with Domain I-Bound EGFsEGFR is shown in CPK representation, with subdomains colored as in Figure 1. Bound EGF is magenta. EGF is intimately associated with domain I (blue) but does not come closer than 4 Å away from domain III. The side chain of Y14 (projecting from the left-hand side of EGF) is too distant from domain III to participate in hydrogen bonding.

The above figure is reprinted by permission from Cell Press: Mol Cell (2003, 11, 507-517) copyright 2003.