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Figure 2.
Figure 2. Close-up view of the hOGG1 active site region. a,
Stereo view showing a  A^48-weighted
2F[o] - F[c] electron density map modeled at 1 ,
with elements of the protein and DNA in ball-and-stick models.
The oxoG is red; Lys249, purple; DNA, gold; and the C-N bond
between Lys249 of hOGG1 and C1' of the substrate, pink. b,
Least-squares superposition of the active site region of the
borohydride-trapped complex (same color scheme as in (a), except
side chains are shown in teal) with that of the recognition
complex with the K249Q mutation and an intact oxo-dG lesion21
(PDB entry 1EBM) (gray except Gln249, which is green).
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