|
Figure 2.
Fig. 2. NMR structure of the Hif-1  :TAZ1
complex. (A) Stereo view of the best 20 structures superposed on
backbone heavy atoms in ordered regions. The TAZ1 backbone is
shown in blue, Hif-1 in pink,
and the N and C termini of each chain are labeled in the
corresponding colors. Bound zinc ions are shown as yellow
spheres. (B) Ribbon representation of a single structure in a
similar orientation to A. Helices [1]- [4] of TAZ1
and [A]- [C] of the
Hif-1 CAD are
labeled. The zinc ions are represented as white spheres, and the
side chains of the cysteine and histidine ligands are shown in
yellow and blue, respectively.
|
