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Figure 2.
Figure 2: Solution structure of the ACTR -CBP complex. ACTR
is pink and CBP blue in all figures. a, Stereo view showing
best-fit superposition of backbone heavy atoms within the
structured region. Residues at the boundaries of the structured
region are numbered. b, Ribbon representation, in the same
orientation as a. Helices A  1
-3 and C 1
-3, and the polyglutamine (polyQ) stretch in CBP are labelled.
c, Surface representation of CBP domain, showing the hydrophobic
groove formed by C 1
and C 3
that accommodates helix A 1
of ACTR. The orientation is the same as in a and b. Bulky
hydrophobic residues from A 1
embedded within the groove are labelled. d, Surface
representation of CBP domain, rotated to show the hydrophobic
cleft that binds helix A 2
of ACTR. The interactions between A 3
and C 3
are also shown. Bulky hydrophobic residues of ACTR that form the
molecular interface are labelled, as is Asp 1068, which
participates in the buried salt bridge.
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