Figure 2.
Fig. 2. Structure of human FTase in complex with the
CIFM-derived L-739,750 peptidomimetic and FPP substrate. (A)
Overall structure. (B) 6 F[O]-F[C]
omit electron density for L-739,750. The FPP substrate and zinc
ion are included for reference. (C) Residues forming van der
Waals interactions with L-739,750, shown in stereo. The N
terminus of the peptidomimetic forms an ion pair with an -phosphate
oxygen of the FPP substrate.
F[O]-F[C]
omit electron density for L-739,750. The FPP substrate and zinc
ion are included for reference. (C) Residues forming van der
Waals interactions with L-739,750, shown in stereo. The N
terminus of the peptidomimetic forms an ion pair with an 
-phosphate
oxygen of the FPP substrate.