Figure 2.
Figure 2. The structure of the dual repeat BRCT domain of BRCA1.
a, A ribbons representation of the BRCT domain. The secondary
structure elements in the C-terminal BRCT repeat are labeled
'prime' to distinguish them from the corresponding secondary
structure elements in the N-terminal repeat. b, C backbone
trace of the BRCA1 BRCT domain. The N-terminal BRCT repeat is
colored turquoise; the C-terminal repeat, gold; and the
inter-repeat linker, gray. The view is rotated 90° clockwise
from the view shown in (a). c, MAD-phased electron density at
2.9 Å resolution and contoured at 1.0 is
displayed for the inter-BRCT repeat interface. d, A stereo view
of a structural alignment of the N- and C-terminal BRCA1 BRCT
repeats and the C-terminal BRCT repeat from XRCC1 (ref. 10).
Least squares alignments were produced using O23.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nat Struct Biol
(2001,
8,
838-842)
copyright 2001.
backbone
trace of the BRCA1 BRCT domain. The N-terminal BRCT repeat is
colored turquoise; the C-terminal repeat, gold; and the
inter-repeat linker, gray. The view is rotated 90° clockwise
from the view shown in (a). c, MAD-phased electron density at
2.9 Å resolution and contoured at 1.0 
is
displayed for the inter-BRCT repeat interface. d, A stereo view
of a structural alignment of the N- and C-terminal BRCA1 BRCT
repeats and the C-terminal BRCT repeat from XRCC1 (ref. 10).
Least squares alignments were produced using O23.