Figure 2.
Figure 2. Human BVR-B binds specifically to NADP. a, Stereo
view of the NADP+ cofactor binding site. Putative hydrogen bonds
are shown as dotted green lines, and solvent molecules as red
spheres. The atom color code is the same as in Fig. 1b. The 1.15
Å 2F[o] - F[c] electron density map for the cofactor, contoured
at 1.5 ,
is shown in blue. Residues interacting with NADP+ are numbered.
b, Solid surface representation of human BVR-B in complex with
NADP+ showing the wide substrate binding site adjacent to the
cofactor. Electrostatic surface potentials are contoured from
-10 (red) to 10 (blue) k[B]T e^-1. The cofactor carbon atoms are
shown in white, phosphorous in yellow, nitrogens in blue and
oxygens in red.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nat Struct Biol
(2001,
8,
215-220)
copyright 2001.
,
is shown in blue. Residues interacting with NADP+ are numbered.
b, Solid surface representation of human BVR-B in complex with
NADP+ showing the wide substrate binding site adjacent to the
cofactor. Electrostatic surface potentials are contoured from
-10 (red) to 10 (blue) k[B]T e^-1. The cofactor carbon atoms are
shown in white, phosphorous in yellow, nitrogens in blue and
oxygens in red.