|
Figure 2.
Figure 2. Structure of the PTP1B Bisphosphorylated IR
Peptide Complex(A) Overview. The PTP loop (residues 215–222)
of PTP1B is shown in yellow, the WPD loop (residues 179-185) in
maroon, the pTyr loop (residues 45–49) in purple, and the Q
loop (residues 258–262) in pink.(B) Stereo view showing
details of the interactions between the bisphosphorylated IRK
peptide and PTP1B.(C) 2F[o]-F[c] electron density omit map,
contoured at the 1 σ level, for the IRK peptide; only pTyr-1162
was included in the refinement and phase calculation of the map.
|
