Figure 2 - full size

 

Figure 2.
Figure 2. Least-squares superposition of four lysozyme crystal structures in complex with their respective antibody Fv fragments: scFv 1F9 in red, Fv D1.3 in blue (PDB entry 1VFB, [Bhat et al 1994]), Fv fragment of HyHEL-5 Fab in orange (PDB entry 3HFL, [Cohen et al 1996]) and Fv fragment of HyHEL-10 Fab in light blue (PDB entry 3HFM, [Padlan et al 1989]). This antibody-antigen complexes, shown as stereographic a-carbon traces generated by SETOR [Evans 1993], are examples for the three different epitope regions on lysozyme described in crystal structures. The disulfide bridges are drawn in yellow.

The above figure is reprinted by permission from Elsevier: J Mol Biol (2000, 301, 239-246) copyright 2000.