Figure 2.
Figure 2. Structural changes between Arf1 and Arf6. a,
Close-up view of the most divergent regions. Arf6 is shown in
blue, Arf1 in white. Differences are located at the N-terminal
helix, the linker, the switch I and II regions and the
interswitch loop. Sequence changes important for the distinctive
conformation of Arf6 are shown in red; their counterparts in
Arf1 are in yellow and are labeled with an asterisk. The -strands
in the interswitch region have similar conformations in Arf1 and
Arf6 and are shown for Arf6 only (in gray). The orientation is
as in Fig. 1b. b, Stereo view of the F[o] - F[c] electron
density map near the Ser 38 -Glu 50 hydrogen bond, contoured at
3 ,
with shown residues omitted from the calculation.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nat Struct Biol
(2000,
7,
466-469)
copyright 2000.
-strands
in the interswitch region have similar conformations in Arf1 and
Arf6 and are shown for Arf6 only (in gray). The orientation is
as in Fig. 1b. b, Stereo view of the F[o] - F[c] electron
density map near the Ser 38 -Glu 50 hydrogen bond, contoured at
3 
,
with shown residues omitted from the calculation.