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Figure 2.
Fig. 2. L-3-Hydroxyacyl-CoA dehydrogenase complexed with
the substrate, 3-hydroxybutyryl-CoA. The ribbon diagram depicts
the two-domain structure of an HAD subunit, with the first 200
amino acids comprising the NAD +-binding domain and the
remaining residues comprising the C-terminal domain.
3-Hydroxybutyryl-CoA, shown in ball and stick representation,
binds within the cleft between these two domains. The adenine
moiety of coenzyme A is positioned adjacent to the
helix-turn-helix tail (  2- 3) of the
NAD^+-binding domain, and the acyl chain is within the enzyme
active site.
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