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Figure 2.
Figure 2: The HFE-TfR interface. Cut away views of a TfR
monomer (a) and the HFE platform (b) from the HFE-TfR structure
are shown with regions containing residues that form contacts
highlighted in gold (HFE) and aqua (TfR). Side chains of
residues identified by site-directed mutagenesis to affect
ligand binding are highlighted on TfR in cyan (Fe-Tf binding28)
and on HFE in red (TfR binding12). c, Representation of HFE-TfR
interface showing the three-helix bundle and kinked portion of
the HFE  2
helix. d, TCR footprint (pink box) on the structure of a class I
MHC molecule. Arrows indicate the 'high points' on the 1
and 2
helices (Based on Fig. 5 in ref. 4).
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