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Figure 1.
Fig. 1. The arm-exchange interface. (A) Ribbon structure of
the EphB2 SAM domain. The L-form of the polypeptide is outlined
in blue, the S-form is outlined in yellow, and Tyr8 is shown in
ball and stick representation. The areas of the structure that
interact with other proteins are highlighted in red. In our
numbering, Tyr26 corresponds to Tyr929 in the EphB1 receptor
(23). (B) Close-up view of the L-form peptide insertion. In the
L-form, Tyr8 packs into a hydrophobic pocket (Phe^11 is not
shown, Phe^38, Met70, Trp17, and Val69) and hydrogen bonds
through an ordered water molecule to Ser66. (C) Close-up view of
the S-form peptide insertion. In the S-form, Tyr8 inserts into
the same pocket as in the L-form, but it hydrogen bonds to Trp17
through an ordered water molecule. Residue Phe^11C (L-form) and
helix 1 are shown in transparent representation to better
illustrate the packing around Tyr8 and the architecture of Trp17
in the hydrophobic patch. The figures were made with MOLSCRIPT
(33).
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