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Figure 1.
Figure 1. Comparison of the Diagonal Binding Modes of the
Human B7 TCR and A6 TCR Bound to the HLA-A2/HTLV-1 Tax Peptide
Complex(A) Shown are the three variable or CDR loops of B7 TCR
Vα (red) and Vβ (yellow); A6 TCR (blue); HLA (dark blue); and
peptide (white). The variable loop 4 of Vα is omitted because
it makes no contacts in the B7 TCR complex.(B) The Vα and Vβ
domains of each TCR bound to HLA-A2 (colors as in [A]). The
α[1]α[2] domains of HLA-A2 from each TCR/MHC structure are
superimposed.(C) TCR/HLA-A2/Tax complexes are compared by
superimposing the HLA-A2 (blue) molecule. B7 TCR (red); A6 TCR
(green). B7–CDR2β contacts HLA-A2 (arrow); A6–CDR2β does
not.(D) Vα (blue)–Vβ (red) interface in B7 and A6 (light
colors). β chains of B7 and A6 are superimposed.Figure drawn
with RIBBONS ([6]).
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