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Figure 1.
Fig. 1. Schematic: i, circulating antithrombin; ii, contacts
endothelial heparans with induction of high-affinity binding and
reactive^ site loop exposure; iii-iv, complexes with factor Xa
followed^ by loop cleavage and insertion with diminished heparin
affinity; and v, the complex is released into the circulation
for catabolism by the liver.
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