Figure 1 - full size

Figure 1. Figure 1. (a) Reactions catalyzed by scytalone dehydratase. Conversion of scytalone (1) to 1,3,8-trihydroxynaphthalene (2); conversion of vermelone (3) to 1,8-dihydroxynapthalene (4); conversion of an artificial substrate (5) to an α ,β-unsaturated ketone (6). (b) Structure of salicylamide inhibitors; (R)-(+)-N-[1- (4-bromophenyl)ethyl]-5-fluorosalicylamide (7),N-(3,3-diphenylpropyl)-5-fluorosalicylamide (8) and (R)-(+)-N-[1-(4-iodophenyl)ethyl]-5-fluorosalicylamide (9). Figure 1. (a) Reactions catalyzed by scytalone dehydratase. Conversion of scytalone (1) to 1,3,8-trihydroxynaphthalene (2); conversion of vermelone (3) to 1,8-dihydroxynapthalene (4); conversion of an artificial substrate (5) to an α ,β-unsaturated ketone (6). (b) Structure of salicylamide inhibitors; (R)-(+)-N-[1- (4-bromophenyl)ethyl]-5-fluorosalicylamide (7),N-(3,3-diphenylpropyl)-5-fluorosalicylamide (8) and (R)-(+)-N-[1-(4-iodophenyl)ethyl]-5-fluorosalicylamide (9).

The above figure is reprinted by permission from Cell Press: Structure (1994, 2, 937-944) copyright 1994.