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Figure 1.
Interaction between HyHEL-10 Fv and HEL. A, overall structure
of the wild-type HyHEL-10 Fv-HEL complex. The C-α schematic
diagrams of VL, VH, and HEL are shown in green, cyan, and pink,
respectively. The residues investigated in this study are shown
in orange. Interfacial water molecules bridging Fv and HEL are
represented by red balls. B and C, local structure around the
target sites investigated in this study. Interfacial Asn
residues at sites 31, 32 (B), and 92 (C) in the VL participate
in the antigen-antibody interaction by the formation of direct
hydrogen bonds with the antigen. The contacting residues in VL
and HEL are shown by green and pink sticks, respectively. Direct
hydrogen bonds and indirect hydrogen bonds (via interfacial
water molecules) between the antigen and antibody are indicated
by red dotted lines. The figures were generated with WebLab
Viewer (Molecular Simulations Inc., San Diego).
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