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Figure 1.
Cartoon of pST3Gal-I in complex with product CMP and a
disaccharide sugar acceptor (yellow stick model). A model of the
missing lid (residues 305–316) is shown as dashed line
(magenta) based on an equivalent loop in CstII. The catalytic
base (His319) is highlighted in cyan. (a) The GT29 catalytic
domain is linked to the transmembrane helix by a
protease-sensitive stem region. Residues predicted to be
glycosylated are shown as black sticks. (b) The four conserved
sialyl motifs of GT29 STs.
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